KARACHI, PAKISTAN, June 10-The Pakistani Government appealed today to all refugees from East Pakistan to return home and offered a general amnesty extending to military deserters and politicians.

The appeal, issued in Dacca by Lieut. Gen. Tikka Khan, military Governor of East Pakistan, omitted an earlier Government statement that returning refugees would be carefully screened for "anti-state elements."

'It is an amnesty," the Pakistan radio said, "to all classes of people, such as students, laborers, businessmen, industrialists, civil servants, the armed forces and other law enforcement agencies, political workers and leaders, who are welcome to come back."

Pakistan's army was ordered into action in East Pakistan March 25 to suppress the Bengali separatist movement, which was then dominating the province, The army's East Bengal Regiment, the province's police force and all the paramilitary militia forces joined the separatists.

Heavy loss of life followed as the army moved from Dacca to the various districts of East Pakistan, smashing resistance and destroying parts of towns.

The leader of the separatist movement, Sheik Mujibur Rahman, was arrested and most of the leaders of his Awami League went into hiding.

An exodus of refugees from East Pakistan followed. Most refugees crossed into neighboring India, where authorities have estimated that they number up to four million. A cholera epidemic was one of many disasters that befell refugees there.

Today's announcement by Pakistan acknowledged that the refugees were subject to malnutrition and disease and said that they should rejoin their countrymen in the task of reconstruction in East Pakistan.

It said that reception centers had been set up along major routes in East Pakistan near the Indian border to receive returning refugees and to provide food, accommodations, medical assistance and transportation to their homes.

"When they come," the Government announcement said, "They will realize the falsehood of the propaganda of enemies of the state."

It said business, agriculture, industry, schools and communications in East Pakistan were back to normal, and that adequate food stocks were on hand.